開催概要

• 演題: ”Genetic Engineering of Cells and Animal Models using Zinc Finger Nuclease Technology”

• 講師: Trevor N. Collingwood, PhD (Manager, Technology Research, Research Biotech, SIGMA-Aldrich Co. LLC)

• 日時: 平成24年2月3日(金) 16:30-18:10

• 会場: 京都大学　物質－細胞統合システム拠点（iCeMS=アイセムス） 本館２階セミナー室

• 事前申込: 不要

• 詳細： 添付PDFファイルをご参照下さい。

内容

Zinc Finger Nucleases (ZFNs) are a class of engineered DNA binding proteins that enable targeted modification of the genome by creating site-specific double-strand DNA breaks. The cell’s natural DNA repair processes are then harnessed and controlled to create the desired genomic modification. This approach enables highly efficient targeted gene knockout, point mutation and gene insertion at endogenous loci ZFN technology has been applied to a broad array of cell types for many purposes including understanding basic protein function, creating isogenic cell line models of human disease, tagging of endogenous genes with fluorescent markers. Recent advances in ZFN technology and how it can be applied are opening further opportunities for sophisticated genomic engineering

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